Reaction Details Report a problem with these data
Target
Activin receptor type-1 [147-509]
Ligand
BDBM575163
Substrate
n/a
Meas. Tech.
ALK2 HTRF Assay
IC50
<1±n/a nM
Citation
 Pan, J; Roach, J; Mei, S; He, C; Wu, L; Yao, W Imidazopyridazine and imidazopyridine compounds and uses thereof US Patent  US11459329 Publication Date 10/4/2022 
Target
Name:
Activin receptor type-1 [147-509]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41331.39
Organism:
Homo sapiens (Human)
Description:
aa147-end
Residue:
363
Sequence:
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM575163
Synonyms:
US11459329, Example 37
Type:
Small organic molecule
Emp. Form.:
C29H26N8O
Mol. Mass.:
502.5697
SMILES:
Cc1nn2c(cnc2cc1-c1cnn(c1)[C@H]1CC[C@H](O)CC1)-c1ccnc2nc(ccc12)-c1ccccn1 |r,wU:18.21,wD:15.17,(-.29,-1.34,;-1.2,-2.58,;-2.73,-2.42,;-3.63,-3.67,;-5.17,-3.83,;-5.49,-5.33,;-4.15,-6.1,;-3.01,-5.07,;-1.48,-5.23,;-.57,-3.99,;.96,-4.15,;1.73,-5.48,;3.24,-5.16,;3.4,-3.63,;1.99,-3.01,;4.73,-2.86,;6.07,-3.63,;7.4,-2.86,;7.4,-1.32,;8.73,-.55,;6.07,-.55,;4.73,-1.32,;-6.2,-2.68,;-7.7,-3,;-8.73,-1.86,;-8.26,-.39,;-6.75,-.07,;-6.27,1.39,;-4.77,1.71,;-3.74,.57,;-4.21,-.9,;-5.72,-1.22,;-4.29,3.18,;-5.32,4.32,;-4.85,5.78,;-3.34,6.1,;-2.31,4.96,;-2.79,3.5,)|
Structure:
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