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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM575935
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
7.70±n/a nM
Citation
 Johnson, CN; Buck, IM; Chessari, G; Day, JE; Fujiwara, H; Hamlett, CC; Hiscock, SD; Holvey, RS; Howard, S; Liebeschuetz, JW; Palmer, NJ; St Denis, JD; Twigg, DG; Woodhead, AJ Pharmaceutical compounds US Patent  US11466016 Publication Date 10/11/2022 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM575935
Synonyms:
(1R,2S,3S,5S)-8-[7-(4- chloro-2-methyl-2H- indazol-5-yl)-5H- pyrrolo[2,3-b]pyrazin-3- yl]-2-fluoro-8- azabicyclo[3.2.1]octan- 3-amine | US11466016, Example 64
Type:
Small organic molecule
Emp. Form.:
C21H21ClFN7
Mol. Mass.:
425.89
SMILES:
Cn1cc2c(Cl)c(ccc2n1)-c1c[nH]c2nc(cnc12)N1[C@H]2CC[C@@H]1[C@@H](F)[C@@H](N)C2 |r,TLB:16:20:25.27.29:22.23|
Structure:
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