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Target
Kappa-type opioid receptor
Ligand
BDBM309360
Substrate
n/a
Meas. Tech.
ORL-1 Receptor Binding Assay
Ki
182±29.2 nM
Citation
 Lockman, J; Tafesse, L Ring-contracted morphinans and the use thereof US Patent  US9656962 Publication Date 5/23/2017 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM309360
Synonyms:
(2R,3aS,4R,9bS)-12-(cyclopropylmethyl)- 3a-hydroxy-8-methoxy-1,2,3,3a,4,5- hexahydro-4,9b-(epiminoethano)cyclo- penta[a]naphthalene-2-carboxamide | US9656962, Compound 11
Type:
Small organic molecule
Emp. Form.:
C21H28N2O3
Mol. Mass.:
356.4586
SMILES:
COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(C[C@H](C[C@@]34O)C(N)=O)c2c1 |r,TLB:9:8:19:24.5.6|
Structure:
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