Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM587515
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
40.6±n/a nM
Citation
 Smith, RA; Rideout, DC; Myers, KJ; Kawasaki, A Analogs of dextromethorphan with balanced receptor activities US Patent  US11535596 Publication Date 12/27/2022 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM587515
Synonyms:
US11535596, Compound CNS1-D2
Type:
Small organic molecule
Emp. Form.:
C19H25F2NO
Mol. Mass.:
321.4047
SMILES:
CN1CCC23CCCCC2C1Cc1ccc(OCC(F)F)cc31 |THB:0:1:9:22.12.11,21:22:9:1.3.2|
Structure:
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