Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 14
Ligand
BDBM590228
Substrate
n/a
Meas. Tech.
Usp14 Inhibition Assay
IC50
<50±n/a nM
Citation
 Cullen, M; Bastos, CM; Parks, D; Munoz, B Proteasome activity enhancing compounds US Patent  US11560385 Publication Date 1/24/2023 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 14
Synonyms:
Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14
Type:
PROTEIN
Mol. Mass.:
56058.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103728
Residue:
494
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
  
Inhibitor
Name:
BDBM590228
Synonyms:
US11560385, Compound 4B
Type:
Small organic molecule
Emp. Form.:
C26H28N4O2
Mol. Mass.:
428.5261
SMILES:
Cc1c(cc(C[C@H]2C[C@H](C2)C#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,wU:6.5,8.10,wD:29.33,TLB:23:24:29.31:27.26,THB:30:29:27.26:24,(-3.57,-.98,;-2.24,-.21,;-1.76,1.25,;-.22,1.25,;.25,-.21,;1.74,-.61,;2.83,.48,;2.83,2.02,;4.37,2.02,;4.37,.48,;5.46,3.1,;6.55,4.19,;-.99,-1.12,;-.99,-2.66,;-2.33,-3.43,;-2.33,-4.97,;-.99,-5.74,;.34,-4.97,;.34,-3.43,;-.99,-7.28,;-.99,-8.82,;-2.85,2.34,;-4.34,1.94,;-2.45,3.83,;-3.54,4.92,;-4.64,6,;-3.3,6.77,;-2.9,8.26,;-4.24,7.49,;-5.78,7.49,;-6.55,8.82,;-6.18,6,)|
Structure:
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