Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM593671
Substrate
n/a
Meas. Tech.
Pharmacological Assay
Ki
0.794±n/a nM
Citation
 Runtz-Schmitt, V; Schnider, P; Dolente, C; Fasching, B Spiro-oxazolones US Patent  US11578077 Publication Date 2/14/2023 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM593671
Synonyms:
1'-[4'-oxo-3,4-dihydro-1H,4'H- spiro[naphthalene-2,5'-[1,3]oxazol]- 2'-yl]-1'H,3H-spiro[2-benzofuran- 1,4'-piperidin]-3-one enantiomer A | US11578077, Example 66
Type:
Small organic molecule
Emp. Form.:
C24H22N2O4
Mol. Mass.:
402.4425
SMILES:
O=C1OC2(CCN(CC2)C2=NC(=O)[C@]3(CCc4ccccc4C3)O2)c2ccccc12 |r,t:10|
Structure:
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