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Target
Mannan-binding lectin serine protease 2
Ligand
BDBM32761
Substrate
n/a
Meas. Tech.
Enzymatic Assay for MASP-2
Ki
<1000±n/a nM
Citation
 Cutshall, NS; Gage, JL; Gruswitz, FA; Khalaf, J; Little, TL; Metz, M; Nguyen, JH; Nollert von Specht, PK; Tsoung, J; Cicirelli, M; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Vaddela, SB MASP-2 inhibitors and methods of use US Patent  US11584714 Publication Date 2/21/2023 
Target
Name:
Mannan-binding lectin serine protease 2
Synonyms:
3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2
Type:
PROTEIN
Mol. Mass.:
75689.43
Organism:
Homo sapiens
Description:
ChEMBL_117891
Residue:
686
Sequence:
MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
  
Inhibitor
Name:
BDBM32761
Synonyms:
2-furancarboxylic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-3-pyrazolyl] ester | Furan-2-carboxylic acid 5-amino-1-(4-methoxy-benzenesulfonyl)-1H-pyrazol-3-yl ester | MLS000033887 | SMR000014916 | US11584714, Compound 40# | [5-amino-1-(4-methoxyphenyl)sulfonylpyrazol-3-yl] furan-2-carboxylate | [5-azanyl-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] furan-2-carboxylate | cid_653862 | furan-2-carboxylic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] ester
Type:
Small organic molecule
Emp. Form.:
C15H13N3O6S
Mol. Mass.:
363.345
SMILES:
COc1ccc(cc1)S(=O)(=O)n1nc(OC(=O)c2ccco2)cc1N
Structure:
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