Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM601982
Substrate
n/a
Meas. Tech.
Pim-1 Inhibitory Activity Assay
Ki
0.033±n/a nM
Citation
 Inoue, M; Ogoshi, Y; Furukawa, T; Machida, T; Mitani, I; Harada, K; Nakagawa, Y; Yamaoka, N Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof US Patent  US11643417 Publication Date 5/9/2023 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM601982
Synonyms:
US11643417, Ex. No. 14 | US11643417, Ex. No. 15 | US11643417, Ex. No. 47
Type:
Small organic molecule
Emp. Form.:
C20H21F5N2O4
Mol. Mass.:
448.3838
SMILES:
OCC1CCOC(C1)C(F)(F)CN1CCNC(=O)c2oc3ccc(cc3c12)C(F)(F)F
Structure:
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