Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM602084
Substrate
n/a
Meas. Tech.
Pim-1 Inhibitory Activity Assay
Ki
0.076±n/a nM
Citation
 Inoue, M; Ogoshi, Y; Furukawa, T; Machida, T; Mitani, I; Harada, K; Nakagawa, Y; Yamaoka, N Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof US Patent  US11643417 Publication Date 5/9/2023 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM602084
Synonyms:
US11643417, Ex. No. 110 | US11643417, Ex. No. 99
Type:
Small organic molecule
Emp. Form.:
C23H27F3N2O3
Mol. Mass.:
436.4673
SMILES:
OC1(CC1)C1CCC(CCN2CCNC(=O)c3oc4ccc(cc4c23)C(F)(F)F)CC1 |(7.29,1.98,;6.13,.97,;5.63,-.49,;7.14,-.19,;4.67,1.46,;3.51,.45,;2.05,.95,;1.76,2.46,;.3,2.96,;-.86,1.94,;-2.32,2.44,;-2.5,3.97,;-3.81,4.78,;-5.26,4.26,;-5.76,2.8,;-7.29,2.62,;-4.93,1.51,;-5.56,.1,;-4.41,-.93,;-4.41,-2.47,;-3.08,-3.24,;-1.74,-2.47,;-1.74,-.93,;-3.08,-.16,;-3.4,1.35,;-.41,-3.24,;.92,-2.47,;-.41,-4.78,;.92,-4.01,;2.92,3.47,;4.37,2.98,)|
Structure:
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