Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM602139
Substrate
n/a
Meas. Tech.
Pim-1 Inhibitory Activity Assay
Ki
0.034±n/a nM
Citation
 Inoue, M; Ogoshi, Y; Furukawa, T; Machida, T; Mitani, I; Harada, K; Nakagawa, Y; Yamaoka, N Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof US Patent  US11643417 Publication Date 5/9/2023 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM602139
Synonyms:
US11643417, Ex. No. 149
Type:
Small organic molecule
Emp. Form.:
C22H23F5N2O3
Mol. Mass.:
458.4216
SMILES:
O[C@H]1CC[C@@H](CC1)C(F)(F)CN1CC2(CC2)NC(=O)c2oc3ccc(cc3c12)C(F)(F)F |r,wU:4.7,wD:1.0,(6.71,.26,;5.25,.76,;4.95,2.27,;3.5,2.77,;2.34,1.76,;2.63,.25,;4.09,-.25,;.88,2.25,;-.13,3.41,;1.38,3.71,;-.28,1.24,;-1.74,1.74,;-1.92,3.27,;-3.23,4.08,;-2.61,5.48,;-4.14,5.32,;-4.68,3.56,;-5.18,2.1,;-6.71,1.92,;-4.35,.8,;-4.98,-.6,;-3.83,-1.63,;-3.83,-3.17,;-2.5,-3.94,;-1.16,-3.17,;-1.16,-1.63,;-2.5,-.86,;-2.82,.64,;.17,-3.94,;1.5,-3.17,;.17,-5.48,;1.5,-4.71,)|
Structure:
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