Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM602178
Substrate
n/a
Meas. Tech.
Pim-1 Inhibitory Activity Assay
Ki
0.074±n/a nM
Citation
 Inoue, M; Ogoshi, Y; Furukawa, T; Machida, T; Mitani, I; Harada, K; Nakagawa, Y; Yamaoka, N Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof US Patent  US11643417 Publication Date 5/9/2023 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM602178
Synonyms:
US11643417, Ex. No. 2-06
Type:
Small organic molecule
Emp. Form.:
C22H27F3N2O4
Mol. Mass.:
440.456
SMILES:
C[C@H]1CN(CC[C@H]2CC[C@](O)(CO)CC2)c2c(oc3ccc(cc23)C(F)(F)F)C(=O)N1 |r,wU:6.5,9.9,1.0,wD:9.10,(-3.5,5.55,;-3.66,4.02,;-2.35,3.21,;-2.16,1.68,;-.71,1.18,;.45,2.19,;1.91,1.69,;3.07,2.71,;4.53,2.21,;4.82,.7,;6.16,1.47,;5.59,-.63,;7.13,-.63,;3.67,-.31,;2.21,.18,;-3.25,.58,;-4.78,.74,;-5.4,-.67,;-4.26,-1.7,;-4.26,-3.24,;-2.92,-4.01,;-1.59,-3.24,;-1.59,-1.7,;-2.92,-.93,;-.26,-4.01,;1.08,-3.24,;-.26,-5.55,;1.08,-4.78,;-5.61,2.04,;-7.13,1.85,;-5.11,3.5,)|
Structure:
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