Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM484121
Substrate
n/a
Meas. Tech.
Radioligand Assay
Ki
<100±n/a nM
Citation
Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C Oxadiazaspiro compounds for the treatment of drug abuse and addiction US Patent US11649248 Publication Date 5/16/2023
More Info.:
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
Inhibitor
Name:
BDBM484121
Synonyms:
8-(2-(3-fluoropyridin-2-yl)ethyl)-12-isobutyl-4- oxa-8,12-diazadispiro[2.1.5.3]tridecane | US10927128, Example 42 | US11649248, Example 42
Type:
Small organic molecule
Emp. Form.:
C21H32FN3O
Mol. Mass.:
361.4967
SMILES:
CC(C)CN1CC2(CC2)OC2(CCN(CCc3ncccc3F)CC2)C1