Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM606328
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
102±n/a nM
Citation
 Froidevaux, S; Hubler, F; Murphy, M; Renneberg, D; Stamm, S C5a receptor modulators US Patent  US11685729 Publication Date 6/27/2023 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM606328
Synonyms:
US11685729, Example 49 | {3-[1-(2-Fluoro-6-methyl-phenyl)-piperidin-4-yl]-2-oxo-3,4-dihydro-2H-quinazolin-1-yl}-(2-methoxy-phenyl)-aceticacid methyl ester
Type:
Small organic molecule
Emp. Form.:
C30H32FN3O4
Mol. Mass.:
517.5912
SMILES:
COC(=O)C(N1C(=O)N(Cc2ccccc12)C1CCN(CC1)c1c(C)cccc1F)c1ccccc1OC
Structure:
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