Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM606340
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
32.0±n/a nM
Citation
 Froidevaux, S; Hubler, F; Murphy, M; Renneberg, D; Stamm, S C5a receptor modulators US Patent  US11685729 Publication Date 6/27/2023 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM606340
Synonyms:
3-[1-(2-Fluoro-6-methyl-phenyl)piperidin-4-yl]-1-[2-(tetrahydro-pyran-4-yloxy)-benzyl]-3,4-dihydro-1H-quinazolin-2-one | US11685729, Example 53
Type:
Small organic molecule
Emp. Form.:
C32H36FN3O3
Mol. Mass.:
529.6449
SMILES:
Cc1cccc(F)c1N1CCC(CC1)N1Cc2ccccc2N(Cc2ccccc2OC2CCOCC2)C1=O
Structure:
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