Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM349324
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay
Ki
41.0±n/a nM
Citation
 Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US11691947 Publication Date 7/4/2023 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM349324
Synonyms:
US10207991, Ex. Cpd. No. 8 | US10611728, Example Compound 8 | US11691947, Example 8
Type:
Small organic molecule
Emp. Form.:
C19H22FNO2
Mol. Mass.:
315.3819
SMILES:
COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O |r|
Structure:
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