Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349566
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay
Ki
10000±n/a nM
Citation
 Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US11691947 Publication Date 7/4/2023 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM349566
Synonyms:
US10207991, Ex. Cpd. No. 84 | US10611728, Example Compound 84 | US11691947, Example 84
Type:
Small organic molecule
Emp. Form.:
C24H32N2O4
Mol. Mass.:
412.5219
SMILES:
COCCNC(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC)c1
Structure:
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