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Target
Apoptosis regulator Bcl-2
Ligand
BDBM608406
Substrate
n/a
Meas. Tech.
BCL-2 TR-FRET Assay
IC50
7.5±n/a nM
Citation
 Kysil, V; Parchinsky, VZ; Pushechnikov, A; Ivachtchenko, AV; Abagyan, R; Orry, A; Lam, PC; Savchuk, N Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors US Patent  US11697650 Publication Date 7/11/2023 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM608406
Synonyms:
N-benzyl-N-(4-hydroxyphenyl)-3-(6-{[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1,3-benzodioxol-5-yl)-5,6,7,8-tetrahydroindolizine-1-carboxamide | US11697650, Compound 15 | US11697650, Example 1
Type:
Small organic molecule
Emp. Form.:
C44H44N4O6
Mol. Mass.:
724.8434
SMILES:
Oc1ccc(cc1)N(Cc1ccccc1)C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12 |r|
Structure:
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