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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM608906
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
26.0±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11702392 Publication Date 7/18/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM608906
Synonyms:
(3P)-6-[(1S)-1-amino-1,3- dihydrospiro[indene-2,4'- piperidin]-1'-yl]-3-(2,3- dichlorophenyl)-2,5-dimethyl-3,4- dihydropyrimidin-4-one | US11702392, Compound 74b
Type:
Small organic molecule
Emp. Form.:
C25H26Cl2N4O
Mol. Mass.:
469.406
SMILES:
Cc1nc(N2CC[C@]3(Cc4ccccc4[C@H]3N)CC2)c(C)c(=O)n1-c1cccc(Cl)c1Cl |r,wU:7.7,wD:15.17,(-4.06,2.64,;-3.29,1.31,;-1.75,1.31,;-.98,-.02,;.56,-.02,;1.33,-1.35,;2.87,-1.35,;3.64,-.02,;4.55,-1.26,;6.01,-.79,;7.34,-1.56,;8.68,-.79,;8.68,.75,;7.34,1.52,;6.01,.75,;4.55,1.23,;4.07,2.69,;2.87,1.32,;1.33,1.31,;-1.75,-1.35,;-.98,-2.69,;-3.29,-1.36,;-4.06,-2.69,;-4.06,-.02,;-5.6,-.02,;-6.37,1.31,;-7.91,1.31,;-8.68,-.03,;-7.91,-1.36,;-8.68,-2.69,;-6.37,-1.36,;-5.6,-2.69,)|
Structure:
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