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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM608920
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
5.00±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11702392 Publication Date 7/18/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM608920
Synonyms:
(3M)-6-[(3R)-3-amino-3H- spiro[furo[2,3-c]pyridine-2,4'- piperidin]-1'-yl]-3-(2,3- dichlorophenyl)-2,5- dimethylpyrimidin-4-one | US11702392, Compound 80c
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2N5O2
Mol. Mass.:
472.367
SMILES:
Cc1nc(N2CC[C@@]3(CC2)Oc2cnccc2[C@H]3N)c(C)c(=O)n1-c1cccc(Cl)c1Cl |r,wD:7.10,17.20,(-4.01,2.64,;-3.23,1.31,;-1.69,1.31,;-.92,-.02,;.62,-.02,;1.39,1.31,;2.93,1.32,;3.7,-.02,;2.93,-1.35,;1.39,-1.35,;4.6,-1.26,;6.07,-.78,;7.4,-1.55,;8.73,-.78,;8.73,.76,;7.4,1.53,;6.07,.76,;4.6,1.23,;4.12,2.69,;-1.69,-1.36,;-.92,-2.69,;-3.23,-1.36,;-4,-2.69,;-4,-.03,;-5.65,-.03,;-6.42,-1.36,;-7.96,-1.37,;-8.73,-.03,;-7.96,1.3,;-8.73,2.63,;-6.42,1.3,;-5.65,2.64,)|
Structure:
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