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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM608950
Substrate
n/a
Meas. Tech.
SHP2 Biochemical Assay
IC50
7.00±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11702392 Publication Date 7/18/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM608950
Synonyms:
3-4-[(1S)-1-amino-1,3- dihydrospiro[indene-2,4'- piperidin]-1'-yl]-2,5-dimethyl-6- oxo-1,6-dihydropyrimidin-1-yl-2- chlorobenzonitrile | US11702392, Compound 108
Type:
Small organic molecule
Emp. Form.:
C26H26ClN5O
Mol. Mass.:
459.971
SMILES:
Cc1nc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)c(C)c(=O)n1-c1cccc(C#N)c1Cl |r,wU:15.17,(3.53,-2.02,;2.76,-.69,;1.22,-.69,;.45,.65,;-1.09,.65,;-1.86,1.98,;-3.4,1.98,;-4.17,.65,;-5.08,-.6,;-6.54,-.12,;-7.87,-.89,;-9.21,-.12,;-9.21,1.42,;-7.87,2.19,;-6.54,1.42,;-5.08,1.89,;-4.6,3.36,;-3.4,-.69,;-1.86,-.69,;1.22,1.98,;.45,3.31,;2.76,1.98,;3.53,3.31,;3.53,.65,;5.36,.65,;6.13,1.98,;7.67,1.98,;8.44,.65,;7.67,-.69,;8.44,-2.02,;9.21,-3.36,;6.13,-.69,;5.36,-2.02,)|
Structure:
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