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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM310926
Substrate
n/a
Meas. Tech.
Enzyme Assay Data on TC-PTP
IC50
170±n/a nM
Citation
 Tremblay, ML; Penafuerte, C; Feldhammer, M; Zogopoulos, G; Black, C; Kennedy, B TC-PTP inhibitors as APC activators for immunotherapy US Patent  US10150787 Publication Date 12/11/2018 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM310926
Synonyms:
((5-Bromo-2-(Carboxy)Benzo[b]Thiophen-6-yl)Difluoromethyl)Phosphonate | US10150787, Example 9 | US11597739, Example 9
Type:
Small organic molecule
Emp. Form.:
C10H6BrF2O5PS
Mol. Mass.:
387.091
SMILES:
OC(=O)c1cc2cc(Br)c(cc2s1)C(F)(F)P(O)(O)=O
Structure:
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