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Target
Mitogen-activated protein kinase 1
Ligand
BDBM609996
Substrate
n/a
Meas. Tech.
ERK2 Enzymatic Assay
IC50
<10±n/a nM
Citation
 Guichou, J; Bories, C; Geoffroy, C; Duquenne, C; Gelin, M; Labesse, G; Bessin, Y; Mathieu, L Azaindole derivatives and their use as ERK kinase inhibitors US Patent  US11708364 Publication Date 7/25/2023 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM609996
Synonyms:
1-(3-Chloro-2-fluorobenzyl)-4-(5-(6-hydroxy-1,4-oxazepan-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2(1H)-one | US11708364, Example 120
Type:
Small organic molecule
Emp. Form.:
C24H22ClFN4O3
Mol. Mass.:
468.908
SMILES:
OC1COCCN(C1)c1cnc2[nH]cc(-c3ccn(Cc4cccc(Cl)c4F)c(=O)c3)c2c1
Structure:
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