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Target
Mitogen-activated protein kinase 1
Ligand
BDBM495249
Substrate
n/a
Meas. Tech.
ERK2 Enzymatic Assay
IC50
<10±n/a nM
Citation
 Guichou, J; Bories, C; Geoffroy, C; Duquenne, C; Gelin, M; Labesse, G; Bessin, Y; Mathieu, L Azaindole derivatives and their use as ERK kinase inhibitors US Patent  US11708364 Publication Date 7/25/2023 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM495249
Synonyms:
1-(2-Chloro-3-fluorobenzyl)-4-(5-morpholino-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2(1H)-one | US10995089, Example 226 | US11708364, Example 226
Type:
Small organic molecule
Emp. Form.:
C23H20ClFN4O2
Mol. Mass.:
438.882
SMILES:
Fc1cccc(Cn2ccc(cc2=O)-c2c[nH]c3ncc(cc23)N2CCOCC2)c1Cl
Structure:
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