Reaction Details Report a problem with these data
Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50607643
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
1.70±n/a nM
Citation
 Markowitz, S; Yuan, Y; Zhang, Y; Ready, J; Hu, B Compositions and methods of modulating short-chain dehydrogenase US Patent  US11718589 Publication Date 8/8/2023 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50607643
Synonyms:
CHEMBL5220207 | US11718589, Compound 49b
Type:
Small organic molecule
Emp. Form.:
C23H20N4O
Mol. Mass.:
368.4311
SMILES:
O=C(N1CCCCC1)c1ccc2ncc(nc2c1)-c1ccc2cnccc2c1
Structure:
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