Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50320733
Substrate
n/a
Meas. Tech.
HDAC Inhibition Assay
IC50
>50000±n/a nM
Citation
 Liao, D; Roush, WR; Stowe, RL HDAC inhibitor compounds and methods of treatment US Patent  US11731934 Publication Date 8/22/2023 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50320733
Synonyms:
2-naphthohydrazide | CHEMBL153973 | Naphthalene-2-carboxylic acid hydrazide | US10807944, Compound RLS2-243 | US11731934, Compound RLS2-243
Type:
Small organic molecule
Emp. Form.:
C11H10N2O
Mol. Mass.:
186.2099
SMILES:
NNC(=O)c1ccc2ccccc2c1
Structure:
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