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Target
Interleukin-17F
Ligand
BDBM617538
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
31.6±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617538
Synonyms:
US20230286943, Example 6
Type:
Small organic molecule
Emp. Form.:
C25H32N6O2
Mol. Mass.:
448.5606
SMILES:
C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cc1)-c1c(C)n[nH]c1C |r,wU:1.0,wD:7.8,4.4,(2.67,5.9,;2.67,4.36,;4,3.59,;4,2.05,;2.67,1.28,;1.33,2.05,;1.33,3.59,;2.67,-.26,;4,-1.03,;4,-2.57,;2.67,-3.34,;5.33,-3.34,;6.74,-2.71,;7.77,-3.86,;7,-5.19,;5.5,-4.87,;4.35,-5.9,;1.33,-1.03,;1.33,-2.57,;,-.26,;-1.33,-1.03,;-2.67,-.26,;-4,-1.03,;-4,-2.57,;-2.67,-3.34,;-1.33,-2.57,;-5.33,-3.34,;-6.74,-2.71,;-7.06,-1.21,;-7.77,-3.86,;-7,-5.19,;-5.5,-4.87,;-4.35,-5.9,)|
Structure:
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