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Target
Interleukin-17F
Ligand
BDBM617543
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
20.0±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617543
Synonyms:
US20230286943, Example 11
Type:
Small organic molecule
Emp. Form.:
C27H34N6O2
Mol. Mass.:
474.5979
SMILES:
CCn1nccc1C(=O)N[C@@H]([C@H]1CC[C@H](C)CC1)C(=O)Nc1ccc(cn1)-c1c(C)cncc1C |r,wU:14.15,wD:11.12,10.10,(3.03,-5.53,;4.52,-5.93,;5.61,-4.84,;7.12,-5.16,;7.89,-3.83,;6.86,-2.68,;5.45,-3.31,;4.12,-2.54,;2.78,-3.31,;4.12,-1,;2.78,-.23,;2.78,1.31,;4.12,2.08,;4.12,3.62,;2.78,4.39,;2.78,5.93,;1.45,3.62,;1.45,2.08,;1.45,-1,;1.45,-2.54,;.11,-.23,;-1.22,-1,;-1.22,-2.54,;-2.55,-3.31,;-3.89,-2.54,;-3.89,-1,;-2.55,-.23,;-5.22,-3.31,;-6.55,-2.54,;-6.55,-1,;-7.89,-3.31,;-7.89,-4.85,;-6.55,-5.62,;-5.22,-4.85,;-3.89,-5.62,)|
Structure:
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