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Target
Interleukin-17F
Ligand
BDBM617544
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
50.1±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617544
Synonyms:
US20230286943, Example 12
Type:
Small organic molecule
Emp. Form.:
C25H34N4O3
Mol. Mass.:
438.5625
SMILES:
C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cc1)C1CCOCC1 |r,wU:1.0,wD:4.3,7.8,(2.12,5.78,;2.12,4.23,;3.45,3.47,;3.45,1.93,;2.12,1.15,;.78,1.93,;.78,3.47,;2.12,-.38,;3.45,-1.15,;4.78,-.38,;4.78,1.15,;6.12,-1.15,;6.28,-2.69,;7.78,-3.01,;8.55,-1.67,;7.52,-.53,;7.92,.96,;.78,-1.15,;.78,-2.69,;-.55,-.38,;-1.89,-1.15,;-1.89,-2.69,;-3.22,-3.47,;-4.55,-2.69,;-4.55,-1.15,;-3.22,-.38,;-5.89,-3.47,;-7.22,-2.69,;-8.55,-3.47,;-8.55,-5,;-7.22,-5.78,;-5.89,-5,)|
Structure:
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