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Target
Interleukin-17F
Ligand
BDBM617590
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
126±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617590
Synonyms:
US20230286943, Example 58
Type:
Small organic molecule
Emp. Form.:
C27H34N6O3
Mol. Mass.:
490.5973
SMILES:
CCn1nccc1C(=O)N[C@@H]([C@H]1CC[C@H](C)CC1)C(=O)Nc1ccc(cn1)-c1c(C)c[n+]([O-])cc1C |r,wU:14.15,wD:10.10,11.12,(3.91,-5.63,;5.41,-5.95,;6.44,-4.8,;7.97,-4.96,;8.6,-3.56,;7.46,-2.52,;6.12,-3.29,;4.79,-2.52,;3.46,-3.29,;4.79,-.98,;3.46,-.21,;3.46,1.33,;4.79,2.1,;4.79,3.64,;3.46,4.41,;3.46,5.95,;2.12,3.64,;2.12,2.1,;2.12,-.98,;2.12,-2.52,;.79,-.21,;-.55,-.98,;-.55,-2.52,;-1.88,-3.29,;-3.21,-2.52,;-3.21,-.98,;-1.88,-.21,;-4.55,-3.29,;-5.88,-2.52,;-5.88,-.98,;-7.21,-3.29,;-7.21,-4.83,;-8.6,-5.6,;-5.88,-5.6,;-4.55,-4.83,;-3.21,-5.6,)|
Structure:
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