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Target
Interleukin-17F
Ligand
BDBM617639
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
100±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617639
Synonyms:
US20230286943, Example 107
Type:
Small organic molecule
Emp. Form.:
C24H31N7O3
Mol. Mass.:
465.548
SMILES:
CCc1nocc1C(=O)N[C@@H]([C@H]1CC[C@H](C)CC1)C(=O)Nc1ccc(cn1)-c1c(C)nnn1C |r,wU:14.15,wD:11.11,10.10,(3.62,-3.39,;5.12,-3.72,;6.15,-2.57,;7.65,-2.89,;8.42,-1.56,;7.39,-.41,;5.99,-1.04,;4.65,-.27,;4.65,1.27,;3.32,-1.04,;1.98,-.27,;1.98,1.27,;3.32,2.04,;3.32,3.58,;1.98,4.35,;1.98,5.89,;.65,3.58,;.65,2.04,;.65,-1.04,;.65,-2.58,;-.68,-.27,;-2.02,-1.04,;-2.02,-2.58,;-3.35,-3.35,;-4.68,-2.58,;-4.68,-1.04,;-3.35,-.27,;-5.99,-3.4,;-6.15,-4.93,;-4.94,-5.89,;-7.65,-5.25,;-8.42,-3.92,;-7.39,-2.78,;-7.75,-1.28,)|
Structure:
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