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Target
Interleukin-17F
Ligand
BDBM617654
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
79.4±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617654
Synonyms:
US20230286943, Example 122
Type:
Small organic molecule
Emp. Form.:
C25H31N5O4
Mol. Mass.:
465.5447
SMILES:
CCc1nocc1C(=O)N[C@@H]([C@H]1CC[C@H](C)CC1)C(=O)Nc1ccc(nc1)-c1c(C)noc1C |r,wU:14.15,wD:10.10,11.18,(3.55,-3.12,;5.02,-3.59,;6.16,-2.56,;7.67,-2.88,;8.44,-1.55,;7.41,-.4,;6,-1.03,;4.67,-.26,;4.67,1.28,;3.33,-1.03,;2,-.26,;2,1.28,;3.33,2.05,;3.33,3.59,;2,4.36,;2,5.9,;.67,3.59,;.67,2.05,;.67,-1.03,;.67,-2.57,;-.67,-.26,;-2,-1.03,;-3.33,-.26,;-4.67,-1.03,;-4.67,-2.57,;-3.33,-3.34,;-2,-2.57,;-6,-3.34,;-6.16,-4.87,;-5.02,-5.9,;-7.67,-5.19,;-8.44,-3.86,;-7.41,-2.71,;-7.73,-1.21,)|
Structure:
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