Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM212563
Substrate
n/a
Meas. Tech.
Inhibitory Activity Against Human Renin
IC50
2.50±n/a nM
Citation
 Iijima, T; Sugama, H; Kawaguchi, T; Shen, J; Xia, G; Xie, J; Hirai, M Nitrogen-containing saturated heterocyclic compound US Patent  US10155731 Publication Date 12/18/2018 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM212563
Synonyms:
US10155731, Example 276 | US9278944, 139 | US9278944, 276
Type:
Small organic molecule
Emp. Form.:
C22H34N2O4
Mol. Mass.:
390.5164
SMILES:
COCCCCc1cc(ccc1OC)[C@@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1 |r|
Structure:
Search PDB for entries with ligand similarity: