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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM622537
Substrate
n/a
Meas. Tech.
PLK1 Inhibition Assay
Ki
>4000±n/a nM
Citation
 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P PTERIDINONE COMPOUNDS AND USES THEREOF US Patent  US20230312587 Publication Date 10/5/2023 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM622537
Synonyms:
5,8-dimethyl-7-propyl-2-(((1-(3,4,5-trifluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one | US20230312587, Compound 23
Type:
Small organic molecule
Emp. Form.:
C22H24F3N7O
Mol. Mass.:
459.4675
SMILES:
CCCC1N(C)c2nc(NCc3cnn(Cc4cc(F)c(F)c(F)c4)c3)ncc2N(C)C1=O
Structure:
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