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Target
Protein kinase C beta type Isoform 2
Ligand
BDBM286380
Substrate
n/a
Meas. Tech.
Protein Kinase C beta 2 (PKCpII) Assay
Ki
4.24±n/a nM
Citation
 Li, H; Nukui, S; Scales, SA; Teng, M; Yin, C Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors US Patent  US11780853 Publication Date 10/10/2023 
Target
Name:
Isoform Beta-II of Protein kinase C beta type (PRKCB2)
Synonyms:
KPCB_HUMAN | PKCB | PRKCB | PRKCB1 | Protein kinase C beta II type | Protein kinase C beta type (PRKCB2)
Type:
Enzyme
Mol. Mass.:
77017.33
Organism:
Homo sapiens (Human)
Description:
P05771-2
Residue:
673
Sequence:
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS
  
Inhibitor
Name:
BDBM286380
Synonyms:
N-(4-ethoxypyrimidin-2-yl)-6,6-dimethyl-5-{[(2S,5R)-2,4,5-trimethylpiperazin-1-yl]carbonyl}-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine | US11220518, Ex. No. M1 | US11780853, Example M1 | US9518060, Example M1
Type:
Small organic molecule
Emp. Form.:
C21H32N8O2
Mol. Mass.:
428.5312
SMILES:
CCOc1ccnc(Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C)C[C@@H]2C)C3(C)C)n1 |r|
Structure:
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