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Target
Transcriptional enhancer factor TEF-5
Ligand
BDBM626324
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
2400±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-5
Synonyms:
DTEF-1 | TEA domain family member 3 | TEAD-3 | TEAD3 | TEAD3_HUMAN | TEAD5 | TEF5 | Transcriptional enhancer factor TEF-5
Type:
PROTEIN
Mol. Mass.:
48683.38
Organism:
Homo sapiens
Description:
ChEMBL_119185
Residue:
435
Sequence:
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
  
Inhibitor
Name:
BDBM626324
Synonyms:
2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobenzofuran-5- yl]amino]methyl]prop-2- enehydroxamic acid | US11787775, Compound 29 | US11787775, Compound 9
Type:
Small organic molecule
Emp. Form.:
C22H23N3O3
Mol. Mass.:
377.4363
SMILES:
CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(=O)NO)c(C#N)c2CCOc12
Structure:
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