Reaction Details Report a problem with these data
Target
Transcriptional enhancer factor TEF-5
Ligand
BDBM626358
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
660±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-5
Synonyms:
DTEF-1 | TEA domain family member 3 | TEAD-3 | TEAD3 | TEAD3_HUMAN | TEAD5 | TEF5 | Transcriptional enhancer factor TEF-5
Type:
PROTEIN
Mol. Mass.:
48683.38
Organism:
Homo sapiens
Description:
ChEMBL_119185
Residue:
435
Sequence:
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
  
Inhibitor
Name:
BDBM626358
Synonyms:
2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3- benzothiazol-6- yl]amino]methyl]prop-2- enehydroxamic acid | US11787775, Compound 41
Type:
Small organic molecule
Emp. Form.:
C19H13F3N4O3S
Mol. Mass.:
434.392
SMILES:
ONC(=O)C(=C)CNc1cc(-c2ccc(OC(F)(F)F)cc2)c2ncsc2c1C#N
Structure:
Search PDB for entries with ligand similarity: