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Target
Transcriptional enhancer factor TEF-5
Ligand
BDBM626365
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
1200±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-5
Synonyms:
DTEF-1 | TEA domain family member 3 | TEAD-3 | TEAD3 | TEAD3_HUMAN | TEAD5 | TEF5 | Transcriptional enhancer factor TEF-5
Type:
PROTEIN
Mol. Mass.:
48683.38
Organism:
Homo sapiens
Description:
ChEMBL_119185
Residue:
435
Sequence:
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
  
Inhibitor
Name:
BDBM626365
Synonyms:
2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)phenyl]-1,3- benzothiazol-6- yl]amino]methyl]prop-2- enehydroxamic acid | US11787775, Compound 51
Type:
Small organic molecule
Emp. Form.:
C18H13F5N4O2S2
Mol. Mass.:
476.443
SMILES:
ONC(=O)C(=C)CNc1cc(-c2ccc(cc2)S(F)(F)(F)(F)F)c2ncsc2c1C#N
Structure:
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