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Target
Lysyl oxidase homolog 3
Ligand
BDBM461421
Substrate
n/a
Meas. Tech.
Human LOXL3 Purified Recombinant Protein Assay
IC50
1210±0 nM
Citation
 Bain, G; Evans, JF; Mackenna, DA; Hutchinson, JH Uses of a lysyl oxidase-like 2 inhibitor US Patent  US11793797 Publication Date 10/24/2023 
Target
Name:
Lysyl oxidase homolog 3
Synonyms:
1.4.3.- | 1.4.3.13 | LOXL | LOXL3 | LOXL3_HUMAN | Lysyl oxidase homolog 3 | Lysyl oxidase-like protein 3 | Synonyms=LOXL
Type:
PROTEIN
Mol. Mass.:
83173.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117594
Residue:
753
Sequence:
MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
  
Inhibitor
Name:
BDBM461421
Synonyms:
US10774069, Compound 1 | US11072585, Example 120 | US11459309, Compound 2 | US11793797, Compound 1
Type:
Small organic molecule
Emp. Form.:
C18H17F4N3O3
Mol. Mass.:
399.3395
SMILES:
NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F |r|
Structure:
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