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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM635452
Substrate
n/a
Meas. Tech.
Enzymatic BRAF Kinase Activity Assay
IC50
5.5±n/a nM
Citation
 Kanouni, T; Cox, JM; Tyhonas, J; Kania, RS; Chakravorty, SJ; Chen, YK Inhibtors of Raf kinases US Patent  US11814384 Publication Date 11/14/2023 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM635452
Synonyms:
N-(1-(tert-butyl)-5-fluoro-1H-pyrazol-4-yl)-2- fluoro-4-methyl-5-(2-methyl-5-morpholino- [1,2,4]triazolo[1,5-a]pyridin-7-yl)benzamide | US11814384, Example 283
Type:
Small organic molecule
Emp. Form.:
C26H29F2N7O2
Mol. Mass.:
509.551
SMILES:
Cc1nc2cc(cc(N3CCOCC3)n2n1)-c1cc(C(=O)Nc2cnn(c2F)C(C)(C)C)c(F)cc1C
Structure:
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