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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM635463
Substrate
n/a
Meas. Tech.
Enzymatic BRAF Kinase Activity Assay
IC50
5.5±n/a nM
Citation
 Kanouni, T; Cox, JM; Tyhonas, J; Kania, RS; Chakravorty, SJ; Chen, YK Inhibtors of Raf kinases US Patent  US11814384 Publication Date 11/14/2023 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM635463
Synonyms:
N-(1-(tert-Butyl)-5-fluoro-1H-pyrazol-4-yl)-2- fluoro-5-(2-isopropyl-8-morpholino- [1,2,4]triazolo[1,5-a]pyridin-6-yl)-4- methylbenzamide | US11814384, Example 308
Type:
Small organic molecule
Emp. Form.:
C28H33F2N7O2
Mol. Mass.:
537.6041
SMILES:
CC(C)c1nc2c(cc(cn2n1)-c1cc(C(=O)Nc2cnn(c2F)C(C)(C)C)c(F)cc1C)N1CCOCC1
Structure:
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