Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM556300
Substrate
n/a
Meas. Tech.
hPGDH Inhibitor Screening Biochemical Assay
IC50
1.80±n/a nM
Citation
 RAI, R; BOOTH, R INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF US Patent  US20230390274 Publication Date 12/7/2023 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM556300
Synonyms:
US11345702, Table 1.18 | US20230390274, Compound A-26
Type:
Small organic molecule
Emp. Form.:
C22H22ClN3O3
Mol. Mass.:
411.881
SMILES:
CCOC(=O)c1nc2cc(ccc2n1-c1cccc(Cl)c1)C(=O)N1CCCCC1 |$;;O;;;;;;;;;;;;;;;;;;;;;;;;;;$|
Structure:
Search PDB for entries with ligand similarity: