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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM640037
Substrate
n/a
Meas. Tech.
hEP2 cAMP Assay
IC50
16.0±n/a nM
Citation
 Boss, C; Corminboeuf, O; Fretz, H; Lyothier, I; Pozzi, D; Richard-Bildstein, S; Siendt, H; Sifferlen, T Pyrimidine derivatives as PGE2 receptor modulators US Patent  US11839613 Publication Date 12/12/2023 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM640037
Synonyms:
2-Ethylsulfanyl-4-{6-[2-(6-methoxy-benzofuran-5-yl)-ethylamino]-pyrimidin-4-yl}- benzoic acid | US11839613, Example 158
Type:
Small organic molecule
Emp. Form.:
C24H23N3O4S
Mol. Mass.:
449.522
SMILES:
CCSc1cc(ccc1C(O)=O)-c1cc(NCCc2cc3ccoc3cc2OC)ncn1
Structure:
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