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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM311863
Substrate
n/a
Meas. Tech.
TDO Coupled Biochemical Assays
IC50
2512±n/a nM
Citation
 Hunter, B; McElroy, S; Wise, A Screening method US Patent  US10155972 Publication Date 12/18/2018 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM311863
Synonyms:
US10155972, Compound Incyte 1
Type:
Small organic molecule
Emp. Form.:
C9H7ClFN5O2
Mol. Mass.:
271.636
SMILES:
Nc1nonc1\C(Nc1cc(F)cc(Cl)c1)=N/O
Structure:
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