Reaction Details Report a problem with these data
Target
Lysine--tRNA ligase
Ligand
BDBM50341448
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence Assay
IC50
300000±50000 nM
Citation
 MIRANDE, M; COMISSO, M; DELELIS, O; SUBRA, F INHIBITION OF THE HIV-1 REPLICATION BY COMPOUNDS DIRECTED AGAINST A NEW TARGET OF THE VIRAL CYCLE US Patent  US20230414632 Publication Date 12/28/2023 
Target
Name:
Lysine--tRNA ligase
Synonyms:
KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN
Type:
PROTEIN
Mol. Mass.:
68044.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960665
Residue:
597
Sequence:
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
  
Inhibitor
Name:
BDBM50341448
Synonyms:
4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-phthalazin-1-one | AZELASTINE | Astelin | Astepro | CHEMBL639 | Optilast | Optivar | Rhinolast | US20230414632, Compound II-a | rac-Azelastine
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O
Mol. Mass.:
381.898
SMILES:
CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O
Structure:
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