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Target
Tyrosine-protein kinase BTK [14-552]
Ligand
BDBM324343
Substrate
n/a
Meas. Tech.
In Vitro BTK Kinase Assay
IC50
<1.000±n/a nM
Citation
 Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP; Zheng, F; Peterson, M; Patience, DB Inhibiting agents for bruton's tyrosine kinase US Patent  US11858926 Publication Date 1/2/2024 
Target
Name:
Tyrosine-protein kinase BTK [14-552]
Synonyms:
Tyrosine-protein kinase BTK (14-552)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62318.43
Organism:
Homo sapiens (Human)
Description:
Q06187[14-552]
Residue:
539
Sequence:
SQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT
  
Inhibitor
Name:
BDBM324343
Synonyms:
1-(tert-butyl)-N-((5R)-8- (2-((1-methyl-1H- pyrazol-4- yl)amino)pyrimidin-4- yl)-2-(tetrahydrofuran-3- yl)-2,3,4,5-tetrahydro- 1H-benzo[c]azepin-5-yl)- 1H-1,2,3-triazole-4- carboxamide | US10189829, Compound 121 | US11858926, Compound 121
Type:
Small organic molecule
Emp. Form.:
C29H36N10O2
Mol. Mass.:
556.6619
SMILES:
Cn1cc(Nc2nccc(n2)-c2ccc3[C@@H](CCN(Cc3c2)C2CCOC2)NC(=O)c2cn(nn2)C(C)(C)C)cn1 |r|
Structure:
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