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Target
Tyrosine-protein kinase BTK [14-552]
Ligand
BDBM324379
Substrate
n/a
Meas. Tech.
In Vitro BTK Kinase Assay
IC50
5.50±n/a nM
Citation
 Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP; Zheng, F; Peterson, M; Patience, DB Inhibiting agents for bruton's tyrosine kinase US Patent  US11858926 Publication Date 1/2/2024 
Target
Name:
Tyrosine-protein kinase BTK [14-552]
Synonyms:
Tyrosine-protein kinase BTK (14-552)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62318.43
Organism:
Homo sapiens (Human)
Description:
Q06187[14-552]
Residue:
539
Sequence:
SQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT
  
Inhibitor
Name:
BDBM324379
Synonyms:
5-(tert-butyl)-N-(2- (2-((5- methyl-4,5,6,7- tetrahydropyrazolo[1,5- a]pyrazin-3- yl)amino)pyrimidin-4- yl)-6,7,8,9-tetrahydro- 5H-benzo[7]annulen-5- yl)-1,2,4-oxadiazole-3- carboxamide | US10189829, Compound 113 | US10227341, Compound 113 | US10961237, Compound 113 | US11858926, Compound 113
Type:
Small organic molecule
Emp. Form.:
C29H35N9O2
Mol. Mass.:
541.6473
SMILES:
CN1CCn2ncc(Nc3nccc(n3)-c3ccc4C(CCCCc4c3)NC(=O)c3noc(n3)C(C)(C)C)c2C1
Structure:
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