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Target
Programmed cell death 1 ligand 1
Ligand
BDBM644066
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay-ELISA
IC50
<10±n/a nM
Citation
 Fan, P; Lange, CW; Lui, RM; McMurtrie, DJ; Scamp, RJ; Yang, J; Zeng, Y; Zhang, P Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases US Patent  US11866429 Publication Date 1/9/2024 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM644066
Synonyms:
US11866429, Compound 1.034
Type:
Small organic molecule
Emp. Form.:
C33H33ClN6O2
Mol. Mass.:
581.107
SMILES:
COc1nc(ccc1CN1CC[C@@](C)(O)C1)-c1cccc(c1Cl)-c1cccc(Nc2nc(C)nc3cccnc23)c1C |r|
Structure:
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