Reaction Details Report a problem with these data
Target
Neprilysin
Ligand
BDBM153112
Substrate
n/a
Meas. Tech.
Fluorescence Lifetime-Based Assay
IC50
283±n/a nM
Citation
 Coppola, GM; Iwaki, Y; Karki, R; Kawanami, T; Ksander, GM; Mogi, M; Sun, R Substituted aminobutyric derivatives as neprilysin inhibitors US Patent  US9603819 Publication Date 3/28/2017 
Target
Name:
Neprilysin
Synonyms:
Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11
Type:
Enzyme
Mol. Mass.:
85505.38
Organism:
Homo sapiens (Human)
Description:
P08473
Residue:
750
Sequence:
MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
  
Inhibitor
Name:
BDBM153112
Synonyms:
US8993631, 14-1 | US9006249, Example 1-1 | US9603819, Example 1-1
Type:
Small organic molecule
Emp. Form.:
C26H25NO5
Mol. Mass.:
431.4804
SMILES:
C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cccc(c1)C(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: