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Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM652043
Substrate
n/a
Meas. Tech.
GFP-NFAT translocation assay
IC50
11.3±n/a nM
Citation
 Zhou, Y; He, L Chemical modulators of store-operated calcium channels and their therapeutic applications US Patent  US11905244 Publication Date 2/20/2024 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM652043
Synonyms:
US11905244, Compound 62
Type:
Small organic molecule
Emp. Form.:
C22H22ClN3O4S
Mol. Mass.:
459.946
SMILES:
CCN\C(SC1CC(=O)N(C1=O)c1ccc(cc1)C(=O)OC)=N\c1ccc(C)c(Cl)c1
Structure:
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