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Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM652081
Substrate
n/a
Meas. Tech.
GFP-NFAT translocation assay
IC50
14.8±n/a nM
Citation
 Zhou, Y; He, L Chemical modulators of store-operated calcium channels and their therapeutic applications US Patent  US11905244 Publication Date 2/20/2024 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM652081
Synonyms:
US11905244, Compound 100
Type:
Small organic molecule
Emp. Form.:
C28H28N4O7S2
Mol. Mass.:
596.675
SMILES:
COC(=O)c1ccc(cc1)N1C(=O)CC(S\C(NCCc2ccc(cc2)S(N)(=O)=O)=N\c2ccc(CO)cc2)C1=O
Structure:
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